Keywords

• Toludesvenlafaxine Impurity
• 916918-90-6
• C32H37NO4

Quick Details

• ProName: Toludesvenlafaxine Impurity;916918-90-...
• CasNo: 916918-90-6
• Molecular Formula: C32H37NO4
• Appearance: White to off white powder
• Application: experiment research
• DeliveryTime: prompt delivery
• PackAge: Food bags, aluminum foil bags
• Port: Shenzhen/hongkong
• ProductionCapacity: 5000 Gram/Year
• Purity: 99%+ HPLC
• Storage: cool and dry
• Transportation: DHL,EMS,TNT,UPS,EMS,by air,by sea;
• LimitNum: 10 Milligram
• Moisture Content: 0.1%
• Impurity: 0.1%

Superiority

• Advantages

• High-Purity Guarantee：Confirmed by HPLC with a purity of ≥99.0%, and the structure is verified through multiple methods including NMR (1H, 13C), HRMS, and elemental analysis, providing a reliable reference standard for Toludesvenlafaxine impurity analysis.

• Excellent Stability：Stable for 36 months under storage conditions of -20℃ in the dark and sealed. The degradation rate is less than 0.2% within 6 months in common organic solvents (such as acetonitrile - methanol), ensuring stable and reliable experimental data.

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Details

Toludesvenlafaxine Impurity；916918-90-6

Product Information

• Product Code：T108001

• English Name：Toludesvenlafaxine Impurity 1

• English Alias：4-(2-(dimethylamino)-1-(1-((4-methylbenzoyl)oxy)cyclohexyl)ethyl)phenyl 4-methylbenzoate

• CAS No.：916918-90-6

• Molecular Formula：C??H??NO?

• Molecular Weight：499.64

Applications

• Quality Control Testing：Used for UPLC-MS/MS detection of Impurity 1 in Toludesvenlafaxine API and formulations. Strictly control the impurity content to meet ICH Q3A standards (single impurity limit ≤0.1%), ensuring drug quality and safety.

• Process Optimization Research：Monitor the formation pathway of this impurity during the synthesis of Toludesvenlafaxine. By adjusting parameters such as the esterification reaction temperature (e.g., 60 - 70℃), reaction time, and catalyst dosage, the generation of impurities can be reduced by more than 40%.

• Method Validation：As a standard for developing and validating impurity detection methods, it can effectively verify the resolution (≥3.0) and limit of detection (0.01 ng/mL) of UPLC, ensuring the accuracy and reliability of the detection method.

Background Description

Toludesvenlafaxine is a new-generation antidepressant that regulates neurotransmitter balance and improves depressive symptoms by inhibiting the reuptake of serotonin and norepinephrine. Impurity 1, as a process-related impurity in the synthesis of Toludesvenlafaxine, may originate from side products of reactions such as esterification and amination of intermediates. Functional groups such as benzoyloxy and dimethylamino in its structure may affect drug stability, solubility, and efficacy. With the increasingly strict requirements of global regulatory agencies for impurities in psychiatric drugs, the study of Impurity 1 has become a key part of ensuring the quality and safety of Toludesvenlafaxine.

Research Status

• Application of Advanced Detection Technology：UPLC-MS/MS technology is used, combined with a C18 column (1.7μm) and gradient elution with 0.1% formic acid - acetonitrile. Impurities can be separated within 10 minutes, and the limit of detection is as low as 0.003 ng/mL, enabling high-precision detection of trace impurities.

• In-Depth Study of Formation Mechanism：Studies have shown that Impurity 1 is formed by the esterification reaction of cyclohexyl-containing intermediates with 4-methylbenzoyl chloride under alkaline conditions (such as pyridine/DCM system). Optimizing the reaction sequence, precisely controlling the reactant ratio and reaction time can effectively inhibit side reactions.

• Comprehensive Safety Evaluation：In vitro cytotoxicity experiments show that the IC?? of this impurity against SH-SY5Y nerve cells is 210.6 μM (Toludesvenlafaxine IC?? = 10.5 μM). Although the toxicity is lower than that of the main drug, its content in drugs still needs to be strictly controlled. Currently, long-term stability tests are being carried out to systematically study its degradation characteristics under different humidity, light, and temperature conditions.