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CAS NO.55855-44-2
1(10.0-10000)Milligram
Advantages:N-Nitroso Desmethyl Chlorpromazine is synthesized using advanced technologies and strict purification processes, ensuring extremely high purity and excellent stability. Through precise analytical methods such as nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HRMS), and high-performance liquid chromatography (HPLC), comprehensive structural identification and accurate content determination are carried out on the product, guaranteeing an accurate chemical structure and uniform, stable composition. It can provide a reliable and precise reference substance for drug research, development, and quality testing, effectively reducing experimental errors and significantly enhancing the accuracy and credibility of data.
N-Nitroso Desmethyl Chlorpromazine
English Name:N-Nitroso Desmethyl Chlorpromazine
English Alias:N-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-N-methylnitrous amide
CAS Number:55855-44-2
Molecular Formula:C16H16ClN3OS
Molecular Weight:333.84
Applications:It is mainly applied to the fields of impurity research, quality analysis, and control of Chlorpromazine and related drugs. During the drug research and development process, it can be used to accurately determine the content of this impurity in drugs and evaluate its potential impact on drug safety and effectiveness. In the quality control of pharmaceutical production, as a key reference substance, it can accurately detect the presence of impurities in products, helping enterprises strictly control drug quality and ensure compliance with relevant domestic and international regulations and quality standards. In addition, it also plays an important role in drug stability research, the exploration of drug metabolism pathways, and pharmacological and toxicological evaluations.
Background Description:With the increasingly stringent requirements for drug quality and safety in the pharmaceutical industry, the research on drug impurities has become a crucial part of ensuring drug quality. As a classic antipsychotic drug, the control of impurities in Chlorpromazine is directly related to patient medication safety and treatment effects. N-Nitroso Desmethyl Chlorpromazine, as one of the potential impurities in the drug, in-depth research on its properties, sources, and impacts on the drug is an important part of improving the quality control system of Chlorpromazine drugs, which helps to enhance drug quality and protect patient health. Meanwhile, nitroso impurities are of particular concern to regulatory agencies due to their potential carcinogenic risks, making research on this impurity especially important.
Research Status:Currently, research on N-Nitroso Desmethyl Chlorpromazine is continuously deepening. Researchers are actively exploring more sensitive and efficient detection technologies, such as ultra-high performance liquid chromatography - tandem mass spectrometry (UPLC - MS/MS) technology and high-resolution gas chromatography - mass spectrometry (HRGC - MS) technology, to achieve trace detection and precise quantification of this impurity. At the same time, studies on its generation mechanism during drug synthesis, its interaction mechanism with drug active ingredients, as well as its impact on drug stability and efficacy, are also actively being carried out. In addition, toxicological studies on this impurity, especially the assessment of its potential carcinogenicity, are gradually progressing, aiming to provide more comprehensive and scientific theoretical basis and technical support for the research, development, production, and quality control of Chlorpromazine drugs.