Keywords

• (R)-Flurbiprofen Axetil
• 2375240-97-2
• C19H19FO4

Quick Details

• ProName: (R)-Flurbiprofen Axetil
• CasNo: 2375240-97-2
• Molecular Formula: C19H19FO4
• Appearance: White to off white powder
• Application: experiment research
• DeliveryTime: prompt delivery
• PackAge: Food bags, aluminum foil bags
• Port: Shenzhen/hongkong
• ProductionCapacity: 5000 Gram/Year
• Purity: 99%+ HPLC
• Storage: cool and dry
• Transportation: DHL,EMS,TNT,UPS,EMS,by air,by sea;
• LimitNum: 10 Milligram
• Moisture Content: 0.1%
• Impurity: 0.1%

Superiority

We supply over 20000 types of spot impurity reference materials, with sufficient supply and same day delivery to meet customers' urgent needs for replenishment at any time. The company has its own research and development center and laboratory, and the team members have over ten years of experience in developing drug impurity reference standards. Our website www.molcoo.com covers over 98% of cutting-edge generic drug projects, with complete structural formulas that greatly save customers time in impurity structure analysis and inference. All products undergo strict quality control testing and provide relevant information such as COA, H-NMR, C-NMR, MS/GC-MS, HPLC/GC purity, QNMR quantification, TGA thermogravimetric analysis, IR infrared, UV ultraviolet, two-dimensional (COSY, NOESY, HMBC, HMQC), etc. These structural confirmation spectra ensure quality and reliability. Our products have a wide range of categories, fast delivery time, good quality, and low prices, which can quickly solve various customer needs such as replenishment and consistency evaluation.

Details

(R)-Flurbiprofen Axetil

Product Information

• Product Code：F019051

• English Name：(R)-Flurbiprofen Axetil

• English Alias：(2R)-1-acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate

• CAS No.：2375240-97-2

• Molecular Formula：C??H??FO?

• Molecular Weight：330.35

Advantages

• High Optical Purity：Confirmed by HPLC (ee ≥99.0%), NMR with chiral shift reagents, and X-ray crystallography, suitable for stereoisomer impurity analysis of Flurbiprofen Axetil.

• Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.1% in ethanol-water solution within 6 months.

Applications

• Chiral Impurity Control：Used for UPLC-MS/MS detection of (R)-isomer in Flurbiprofen Axetil API and formulations, controlling optical impurity content to meet ICH Q3A standards (≤0.5%).

• Process Optimization Research：Monitors (R)-Flurbiprofen Axetil formed during asymmetric esterification, improving (S)-isomer selectivity by >90% via adjusting chiral catalyst dosage (e.g., Salen-Co complex) and temperature (0-5℃).

• Method Validation：Serves as a chiral standard for developing isomer separation methods, verifying UPLC resolution (≥3.5) and LOD (0.005 ng/mL).

Background Description

Flurbiprofen Axetil, a non-steroidal anti-inflammatory drug (NSAID), is used for postoperative analgesia, with the (S)-isomer as the active component. The (R)-isomer may exhibit lower anti-inflammatory activity and potential toxicity. As a chiral impurity, (R)-Flurbiprofen Axetil may originate from incomplete racemic resolution or side reactions in asymmetric synthesis. With stricter FDA requirements for chiral drug impurity control, studying such stereoisomers is crucial for ensuring drug safety.

Research Status

• Detection Technology：UPLC-MS/MS with Chiralpak IB column (1.7μm) and n-hexane-ethanol (90:10) gradient elution achieves separation within 4 minutes, with LOD of 0.002 ng/mL for trace chiral impurity analysis.

• Formation Mechanism：Formed by reaction of flurbiprofen with (R)-1-acetoxyethanol under acidic catalysis (e.g., p-toluenesulfonic acid). Using enzymatic catalysis (e.g., porcine pancreatic lipase) or asymmetric hydrogenation reduces (R)-isomer formation by >85%.

• Safety Evaluation：In vitro cytotoxicity shows IC?? of 78.6 μM against THP-1 cells ((S)-Flurbiprofen Axetil IC??=8.2 μM), with low toxicity but requiring ≤0.5% limit. Accelerated stability testing is ongoing to monitor racemization rates under different pH conditions.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.

This product is intended for laboratory use only!

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E-mail: anna@molcoo.com

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