Keywords

• (2S,3R,6RS)-2-(3-Oxobutyl)-3-Methyl-6-[(R)-2-propanal]cyclohexanone
• Artemether Impurity
• 1093625-96-7

Quick Details

• ProName: Artemether Impurity;1093625-96-7
• CasNo: 1093625-96-7
• Molecular Formula: C14H22O3
• Appearance: White to off white powder
• Application: experiment research
• DeliveryTime: prompt delivery
• PackAge: Food bags, aluminum foil bags
• Port: Shenzhen/hongkong
• ProductionCapacity: 5000 Gram/Year
• Purity: 99%+ HPLC
• Storage: cool and dry
• Transportation: DHL,EMS,TNT,UPS,EMS,by air,by sea;
• LimitNum: 10 Milligram
• Moisture Content: 0.1%
• Impurity: 0.1%

Superiority

We supply over 20000 types of spot impurity reference materials, with sufficient supply and same day delivery to meet customers' urgent needs for replenishment at any time. The company has its own research and development center and laboratory, and the team members have over ten years of experience in developing drug impurity reference standards. Our website www.molcoo.com covers over 98% of cutting-edge generic drug projects, with complete structural formulas that greatly save customers time in impurity structure analysis and inference. All products undergo strict quality control testing and provide relevant information such as COA, H-NMR, C-NMR, MS/GC-MS, HPLC/GC purity, QNMR quantification, TGA thermogravimetric analysis, IR infrared, UV ultraviolet, two-dimensional (COSY, NOESY, HMBC, HMQC), etc. These structural confirmation spectra ensure quality and reliability. Our products have a wide range of categories, fast delivery time, good quality, and low prices, which can quickly solve various customer needs such as replenishment and consistency evaluation.

Details

WhatsAPP: +86 17320513646                      E-mail: anna@molcoo.com

Product Information

• Product Code：A116001
• English Name：Artemether Impurity 1
• English Alias：(2R)-2-((3S,4R)-4-methyl-2-oxo-3-(3-oxobutyl)cyclohexyl)propanal
• CAS No.：1093625-96-7
• Molecular Formula：C??H??O?
• Molecular Weight：238.32

Advantages

• High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), and HRMS for stereostructure, suitable for precise analysis of Artemether impurities.
• Stability Assurance：Stable for 24 months at -20℃ under light-protected, sealed storage; degradation rate <0.5% in methanol solution within 3 months.

Applications

• Quality Control Testing：Used for HPLC and LC-MS detection of Impurity 1 in Artemether API and formulations, controlling impurity content to meet ICH Q3A standards (≤0.1%).
• Process Optimization Research：Monitors impurity formation during Artemether synthesis, reducing generation by 60%+ by adjusting epoxidation temperature (e.g., 0-5℃) and reducing agent dosage (e.g., sodium borohydride).
• Method Validation：Serves as a standard for developing impurity detection methods, verifying UPLC resolution (≥2.0) and LOD (0.005 ng/mL).

Background Description

Artemether, a derivative of artemisinin, is a first-line antimalarial drug. Impurity 1 may originate from side reactions during artemisinin synthesis, such as side-chain condensation or cyclohexanone reduction. The oxobutyl group and chiral centers in its structure may affect drug stability and antimalarial activity. With WHO's stricter quality requirements for antimalarials, studying such process impurities is key to ensuring drug efficacy and safety.

Research Status

• Detection Technology：UPLC-MS/MS with chiral C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 3 minutes, with LOD of 0.002 ng/mL meeting WHO trace impurity standards.
• Formation Mechanism：Formed by condensation of (3S,4R)-4-methyl-2-oxocyclohexanone and 3-oxobutanal under alkaline conditions; optimizing reaction pH (7.5-8.0) effectively inhibits side reactions.
• Safety Evaluation：In vitro antimalarial assays show the impurity has IC?? of 12.3 μM against Plasmodium falciparum (Artemether IC??=0.12 μM), with low toxicity but requiring ≤0.1% limit. Long-term stability testing is ongoing to monitor degradation.

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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