Keywords

• Biotin (S)-Sulfoxide
• 10406-89-0
• Biotin, 5-oxide, (+)- (8CI)

Quick Details

• ProName: Biotin (S)-Sulfoxide;10406-89-0
• CasNo: 10406-89-0
• Molecular Formula: C10H16 N2 O4 S
• Appearance: White to off white powder
• Application: for drug impurity for drug standards,f...
• DeliveryTime: 1-2 weeks
• PackAge: 10mg/25mg/50mg/100mg/1000mg/5000mg
• Port: Shenzhen/hongkong
• ProductionCapacity: 5000 Metric Ton/Day
• Purity: 95%+ or 98%+
• Storage: -20℃
• LimitNum: 25 Milligram
• Moisture Content: 0.1%
• Impurity: 0.1%

Superiority

Our products are mainly drug impurity reference products, drug standards, analytical chemistry, standard substances, organic chemical synthesis, chemical custom synthesis. For impurity localization, quantification, and quality control in drug development processes. Our laboratory area is more than 5000 square meters, we have more than 20 analytical instruments such as HPLC and MS/LC-MS/GC-MS, we also have TGA, IR and other testing instruments. We have the most advanced SFC preparation separation equipment. We can provide a full range of impurity reference/standard products required for drug development. Most of the impurities are synthesized through the process, there are also many items of impurities can not be obtained by synthetic means, need to be obtained through raw materials, intermediates, crude products or side reactions contained in the trace target compounds, Hubei Moke has a professional impurity preparation and separation technology team, equipped with professional SFC preparation and separation equipment. It can carry out efficient and accurate separation of impurities for complex projects, and solve the problem of impurity preparation for customers.
 

1. We integrate R&D, production and sales. A 5,000-square-meter high-standard bio-intelligent manufacturing base can ensure high quality and fast delivery of products. The professional sales team ensures that you don't need to worry about pre-sales and after-sales.

2. We focus on pharmaceutical standards, pharmaceutical intermediates, pharmaceutical impurity controls, peptide customization, our own laboratory, and undertake customized synthesis projects.

3. We offer products from gram grade to g grade, in addition, some product specifications and packaging can be customized.

4. We have been deeply engaged in the pharmaceutical field for ten years and have rich experience. At present, customers are all over the world, and have been highly recognized and trusted by customers.

5. We can provide a variety of safe ways to transport goods for you to choose.

Details

Biotin (S)-Sulfoxide

Product Information

• Product Code：B042023

• English Name：Biotin (S)-Sulfoxide

• English Alias：5-((3aS,4S,5S,6aR)-5-oxido-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid

• CAS No.：10406-89-0

• Molecular Formula：CHNOS

• Molecular Weight：260.31

Advantages

• High-Purity Guarantee：Confirmed by HPLC (≥99.0%), combined with multiple techniques such as NMR (1H, 13C), HRMS, and elemental analysis, providing reliable reference materials for biotin-related research.

• Good Stability：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in common solvent systems like methanol - water within 6 months, ensuring the stability and reproducibility of experimental data.

Applications

• Quality Control Testing：Used for UPLC-MS/MS detection of Biotin (S)-Sulfoxide impurity in biotin API and formulations, strictly controlling impurity content to meet ICH Q3A standards (single impurity limit ≤0.1%) and ensuring drug quality.

• Drug Research and Development：During the development of biotin-based drugs, it serves as a reference substance to study its impact on drug activity and stability, helping to optimize the synthesis process and improve drug quality.

• Metabolism Research：As a possible oxidation product of biotin in vivo, it is used to study the metabolic pathways and mechanisms of biotin, facilitating the understanding of drug transformation processes in the body.

Background Description

Biotin, a water-soluble vitamin, plays a crucial role in various physiological processes. It is commonly used to treat conditions such as hair loss and brittle nails and is widely applied in biomedical research and pharmaceutical formulations. Biotin (S)-Sulfoxide, as an oxidation impurity of biotin, may be generated during biotin production and storage due to exposure to oxygen, light, or high temperatures. The sulfoxide group in its structure can change the molecular polarity and chemical properties, potentially affecting the quality, stability, and safety of biotin products. With the increasing requirements for drug impurity control in the pharmaceutical industry, the study of this impurity has become increasingly important.

Research Status

• Detection Technology：UPLC-MS/MS with a C18 column (1.7μm) and 0.1% formic acid - acetonitrile gradient elution achieves separation within 4 minutes, with an LOD as low as 0.003 ng/mL, enabling precise detection of trace impurities.

• Formation Mechanism：Studies have shown that in an aerobic environment, especially under conditions of high temperature, light, or metal ion catalysis, the sulfur atom of biotin is easily oxidized to form Biotin (S)-Sulfoxide. By optimizing the production process, such as using inert gas protection and storing in the dark at low temperatures, the formation of this impurity can be effectively inhibited.

• Safety Evaluation：In vitro cytotoxicity tests show that the IC of this impurity against HepG2 cells is 198.5 μM (biotin has no obvious toxic concentration at tested levels). Although the toxicity is relatively low, its content in drugs still needs to be strictly controlled. Currently, long-term stability tests are being carried out to systematically study its degradation patterns under different humidity, light, and temperature conditions