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Hubei Moxin Biotechnology Co., Ltd

Country: China (Mainland)

Business Type:Lab/Research institutions

Ms.Du

Tel: +86-173-20513646

Mobile: 17320513646

Tel: +86-173-20513646

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URL: http://www.molcoo.com

Province/state: Hu Bei

City: Wuhan

Street: Company address: Room 005, 15th Floor, Building D2, Phase III, Software New Town, No. 8 Huacheng Avenue, East Lake High-tech Development Zone, Wuhan, Hubei Province, China

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Pentoxifylline Impurity

CAS NO.10226-28-5

  • FOB Price: USD: 10.00-10.00 /Metric Ton Get Latest Price
  • Min.Order: 25 Milligram
  • Payment Terms: T/T
  • Available Specifications:

    1(10.0-10000)Metric Ton

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Product Details

Keywords

  • 2-Methyl-3-carbethoxy-5,6-dihydropyran
  • Pentoxifylline Impurity
  • 10226-28-5

Quick Details

  • ProName: Pentoxifylline Impurity
  • CasNo: 10226-28-5
  • Molecular Formula: C9H14O3
  • Appearance: White to off white powder
  • Application: for drug impurity for drug standards,f...
  • DeliveryTime: 1-2 weeks
  • PackAge: 10mg/25mg/50mg/100mg/1000mg/5000mg
  • Port: Shenzhen/hongkong
  • ProductionCapacity: 5000 Metric Ton/Day
  • Purity: 95%+ or 98%+
  • Storage: -20℃
  • LimitNum: 25 Milligram
  • Moisture Content: 0.1%
  • Impurity: 0.1%

Superiority

Our products are mainly drug impurity reference products, drug standards, analytical chemistry, standard substances, organic chemical synthesis, chemical custom synthesis. For impurity localization, quantification, and quality control in drug development processes. Our laboratory area is more than 5000 square meters, we have more than 20 analytical instruments such as HPLC and MS/LC-MS/GC-MS, we also have TGA, IR and other testing instruments. We have the most advanced SFC preparation separation equipment. We can provide a full range of impurity reference/standard products required for drug development. Most of the impurities are synthesized through the process, there are also many items of impurities can not be obtained by synthetic means, need to be obtained through raw materials, intermediates, crude products or side reactions contained in the trace target compounds, Hubei Moke has a professional impurity preparation and separation technology team, equipped with professional SFC preparation and separation equipment. It can carry out efficient and accurate separation of impurities for complex projects, and solve the problem of impurity preparation for customers.
 

1. We integrate R&D, production and sales. A 5,000-square-meter high-standard bio-intelligent manufacturing base can ensure high quality and fast delivery of products. The professional sales team ensures that you don't need to worry about pre-sales and after-sales.

2. We focus on pharmaceutical standards, pharmaceutical intermediates, pharmaceutical impurity controls, peptide customization, our own laboratory, and undertake customized synthesis projects.

3. We offer products from gram grade to g grade, in addition, some product specifications and packaging can be customized.

4. We have been deeply engaged in the pharmaceutical field for ten years and have rich experience. At present, customers are all over the world, and have been highly recognized and trusted by customers.

5. We can provide a variety of safe ways to transport goods for you to choose.

Details

Pentoxifylline Impurity

 

Product Information

  • Product Code:P060024

  • English Name:Pentoxifylline Impurity 24

  • English Alias:ethyl 6-methyl-3,4-dihydro-2H-pyran-5-carboxylate

  • CAS No.:10226-28-5

  • Molecular Formula:C?H??O?

  • Molecular Weight:170.21

Advantages

  • High-Purity Reference Standard:Confirmed by HPLC (≥99.0%), NMR (1H, 13C), IR, and elemental analysis, suitable for Pentoxifylline impurity analysis and quality control.

  • Stability Assurance:Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.5% in methanol-water solution within 6 months.

Applications

  • Quality Control Testing:Used for HPLC and LC-MS detection of Impurity 24 in Pentoxifylline API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).

  • Process Optimization Research:Monitors Impurity 24 formation during Pentoxifylline synthesis, reducing generation by >40% by adjusting cyclization temperature (e.g., 50-60℃) and reaction time.

  • Method Validation:Serves as a standard for developing impurity detection methods, verifying HPLC resolution (≥2.0) and LOD (0.05 ng/mL).

Background Description

Pentoxifylline is a peripheral vasodilator used to improve cerebrovascular and peripheral circulatory disorders. Impurity 24, as a process-related impurity of Pentoxifylline, may originate from alkylation side reactions of the pyran ring or raw material residues during synthesis. Its pyran ring and ester group may affect drug stability and efficacy. With stricter EMA enforcement of EP standards, studying such impurities is crucial for drug registration and manufacturing.

Research Status

  • Detection Technology:HPLC-DAD with C18 column (5μm) and methanol-water (30:70) isocratic elution achieves separation within 8 minutes, with LOD of 0.02 ng/mL for routine impurity analysis.

  • Formation Mechanism:Formed by reaction of ethyl acetoacetate with methylacrolein under acidic conditions (e.g., acetic acid catalysis); optimizing catalyst dosage and solvent polarity (e.g., ethanol-water system) inhibits side reactions.

  • Safety Evaluation:In vitro cytotoxicity shows IC?? of 215.3 μM against HUVEC cells (Pentoxifylline IC??=28.7 μM), with low toxicity but requiring ≤0.1% limit. Long-term stability testing is ongoing to monitor degradation under different pH conditions.

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

 

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The Molcoo Laboratory added drug impurity reference standardsincluding Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 

 

 

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